- WinUAE 4.2.1 and older: Windows XP SP3 (32-bit only)
- Windows 7 or newer recommended (32-bit or 64-bit)
- SSE2 capable CPU.
- Direct3D 11 mode: Windows 7: KB2670838, Windows 8 or newer: no extra dependencies.
- Direct3D 9 mode: June 2010 DirectX 9 redistributable